An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study. Targeting this protein — the ORAI1 calcium channel — could provide a new approach to treating oral cancer, which causes persistent pain that worsens as it progresses. An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study published in led by researchers at NYU College of Dentistry.
“Our results show that the ORAI1 channel fuels the growth of oral cancer tumors and produces an abundance of molecules that, once secreted, interact with neurons resulting in an increased sensitivity to pain,” said Ga-Yeon Son, a postdoctoral fellow in the Department of Molecular Pathobiology at NYU College of Dentistry and the study’s first author.
ORAI calcium channels — named after the three sisters in Greek mythology who guarded the gates of heaven at Mount Olympus — play an important role controlling how much calcium enters cells. “Calcium entering cells is necessary for many good things, but too much calcium for a long time has the opposite effect.” headtopics.com
advertisement Less ORAI1, less cancer growth and pain ORAI1 They then examined human oral cancer cells and found that activating the ORAI1 calcium channel (but not other calcium channels) caused a large influx of calcium into cancer cells.
Hiker, dog rescued after animal falls from Hawaii’s ‘Stairway to Heaven’ trailThe 3,922-step trail is off-limits to hikers.
Conservative propaganda site targeting schools looks to expand state partnershipsAfter striking a deal with Florida schools, conservative propaganda site Prager U. has added a partnership with Oklahoma’s education department while state Republicans elsewhere wrestle with how to bring distorted racial history and other conservative lesson framings to their students.
More gift card scams targeting residents in Northeast OhioPolice said senior citizens are targeted most frequently.
Researchers develop novel tumor-targeting nanospheres to improve light-based cancer diagnosis and treatmentIn a breakthrough in cancer therapeutics, a team of researchers at the Magzoub Biophysics Lab at NYU Abu Dhabi (NYUAD) has made a significant advance in light-based therapies—biocompatible and biodegradable tumor-targeting nanospheres that combine tumor detection and monitoring with potent, light-triggered cancer therapy to dramatically increase the efficacy of existing light-based approaches.
61 ‘anarchists’ indicted by Georgia AG for targeting Atlanta’s ‘Cop City’ training facilityCritics behind the “Stop Cop City” effort, which has been going on for more than two years, believe the $90 million police and fire training center will further militarize police and cause environm…
House Democrats launch $20 million voter registration campaign targeting minoritiesDemocrats are launching a $20 million investment in voter registration that will home in on minority voters in key states as the party seeks to regain control of the House next year.